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Official websites use. Share sensitive information only on official, secure websites. Wahl 1 , W. Liao 1 , M. Chateau 1 , C. Richardson 1 , L. Ling 1 , J. Tucker 1 , I. McGowan 2 , R. Sartor 1 , J. Garcia 1.
Background : Resident microbiota maintain intestinal homeostasis by regulating digestion, metabolism, immune development and providing protection from infection. Pioneering work has also shown that resident microbiota enhance the transmission of a limited number of viruses that target the intestinal tract. The intestinal tract is a major site of HIV infection. However, the effect of resident microbiota on HIV acquisition, replication and pathogenesis in the intestinal tract is unknown due to the strict species tropism of HIV.
First, we rederived a GF strain of immune deficient mice by sterile embryo transfer. All GF mice were housed and experiments performed in sterile gnotobiotic isolators and the GF status of mice confirmed longitudinally. BLT mice colonized with resident microbiota were also constructed.
Results : Our results show that HIV acquisition, replication and pathogenesis in the intestinal tract is greatly enhanced in the presence of resident microbiota. Conclusions : These data directly demonstrate for the first time that resident microbiota are a major driver of HIV acquisition, replication and pathogenesis. Byrnes 1 , K. Angelovich 1 , S. Younger 2 , S. Nekorchuk 2 , S. Bondoc 2 , R. Dannay 2 , M. Terry 2 , C. Cochrane 1 , T. Jenkins 1 , M. Roche 3 , C.
Deleage 4 , S. Bosinger 5 , M. Paiardini 5 , B. Brew 6 , J. Estes 2 , M. Churchill 1. The presence of a viral reservoir and associated neuroinflammation in the brain and ongoing systemic inflammation penetrating the central nervous system CNS are thought to play crucial roles.