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Ref document number : Country of ref document : EP. Kind code of ref document : A1. Country of ref document : CA. Country of ref document : JP. Kind code of ref document : A. Ref country code : DE. Country of ref document : AU. Date of ref document : This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared.
The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
Accordingly, the United States Government has rights in this invention. This invention relates to the fields of genetics, autoimmunity and personalized medicine.
More specifically the invention provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Each of these citations is incorporated by reference herein as though set forth in full.
Color versions of certain figures and tables included herein have also been published in Y. Li et al, Nature Medicine August 24, , online publication doi: High rates of autoimmune disease comorbidity and familial clustering suggest that a strong genetic predisposition may underlie autoimmune disease susceptibility.