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All text from this work may be reprinted freely. Use of these materials should be properly cited. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a bla VIM-4 ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring bla CTX-M in the other.
These isolates formed a new subgroup in the E. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread. Keywords: Carbapenemase, Enterobacter cloacae complex, Enterobacteriaceae , beta-lactamase, nosocomial outbreak, VIM-4, next-generation sequencing, bacteria, antimicrobial resistance, carbapenemase-producing Enterobacteriaceae , CPE.
Controlling the dissemination of carbapenemase-producing Enterobacteriaceae CPE is challenging because carbapenems are among the few antimicrobial drugs that can be used to treat severe infections in this family 1 , 2.
Tzouvelekis et al. Thus, CPEs may carry the threat of a return to the preโantimicrobial drug era. The accurate identification of species and subspecies within the ECC is therefore needed to monitor outbreaks and infections.
