Official websites use. Share sensitive information only on official, secure websites. E-mail: gilberto. We investigated associations of plasma copeptin, a surrogate of vasopressin, and of allelic variations in the arginine vasopressin-neurophysin II gene with insulin secretion, insulin sensitivity, and the risk for impaired fasting glucose IFG and type 2 diabetes mellitus T2DM.
We studied unrelated French men and women from a prospective cohort of the general population Data from Epidemiological Study on the Insulin Resistance Syndrome cohort, 9-y follow-up. Six single nucleotide polymorphisms were genotyped.
Participants in the upper quartile of plasma copeptin had significantly lower insulin sensitivity homeostasis model assessment index at baseline and during follow-up, as compared with other participants.
Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs, the TT genotype of rs, the C-allele of rs, and the CC genotype of rs with the incidence of hyperglycemia.
The genotypes associated with an increased risk of hyperglycemia were also associated with increased plasma copeptin in men but not in women. Moreover, in men, allelic associations support a causal role for vasopressin in these disorders. Allelic associations support a causal role for vasopressin in these disorders. Vasopressin or antidiuretic hormone has many physiological actions in addition to its well-defined role in the control of fluid homeostasis and urine concentration 1 , 2.
