Official websites use. Share sensitive information only on official, secure websites. Correspondence Dr. Legriel stephane. Go to Neurology. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Submitted and externally peer reviewed. To report the prevalence of acute encephalopathy and outcomes in patients with severe coronavirus disease COVID and to identify determinants of day outcomes. Data from adults with severe COVID and acute encephalopathy were prospectively collected for patients requiring intensive care unit management in 31 university or university-affiliated intensive care units in 6 countries France, United States, Colombia, Spain, Mexico, and Brazil between March and September of Acute encephalopathy was defined, as recently recommended, as subsyndromal delirium or delirium or as a comatose state in case of severely decreased level of consciousness.
Logistic multivariable regression was performed to identify factors associated with day outcomes. On multivariable analysis, age older than 70 years odds ratio [OR] 4. Status epilepticus, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome were associated with lower odds of poor day outcome OR 0.
The study is registered with ClinicalTrials. Infection with severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 is dominated predominantly be respiratory symptoms but is notably characterized by a variety of neurologic symptoms with variable severity. The severity of presentation in many cases prompts the consideration of direct neurologic injury.
Acute encephalopathy is a potentially life-threatening condition that clinically corresponds to an alteration of consciousness ranging from delirium to coma, most often rapidly evolving over a period of hours to days.
