Official websites use. Share sensitive information only on official, secure websites. NAFLD decreases life expectancy and increases risks of liver cirrhosis, hepatocellular carcinoma, and the requirement for liver transplantation. We excluded randomised clinical trials in which participants had previously undergone liver transplantation. We included in the review a total of randomised clinical trials 14, participants.
Nineteen trials were at low risk of bias. A total of 32 different interventions were compared in these trials. A total of trials participants were included in one or more comparisons. The remaining trials did not report any of the outcomes of interest for this review.
We did not calculate effect estimates for mortality because of sparse data zero events for at least one of the groups in the trial. The evidence is very uncertain about effects of interventions on serious adverse events number of people or number of events. We are very uncertain about effects on adverse events of most of the supplements that we investigated, as the evidence is of very low certainty. Data were sparse zero events in all groups in the trial for liver transplantation, liver decompensation, and hepatocellular carcinoma.
So, we did not perform formal analysis for these outcomes. The evidence is very uncertain about effects of other antioxidants antioxidants other than vitamins compared to no active intervention on liver cirrhosis HR 1. The evidence is very uncertain about effects of interventions in any of the remaining comparisons, or data were sparse with zero events in at least one of the groups , precluding formal calculations of effect estimates. The reason for the choice of interventions is the impact of these interventions on indirect outcomes, which may translate to clinical benefit.
What is the aim of this Cochrane Review? However, no current evidence suggests that any of them work. Nutritional supplementation has the potential to decrease liver damage, but whether this occurs is currently unclear. The authors of this review collected and analysed all relevant randomised clinical trials with the aim of finding out what is the best treatment. They found randomised clinical trials studies where participants are randomly assigned to one of two treatment groups.
