Official websites use. Share sensitive information only on official, secure websites. One option for managing them is the use of linezolid. A collection of MRSA strains from 68 samples were characterized by determining their linezolid Minimal Inhibitory Concentrations MICs , analyzing the locus of staphylococcal protein A spa and whole genome sequencing. Courses of linezolid were retraced. Strains belonged to three spa types t, t, t and two sequence types ST1, ST5.
Susceptible and resistant strains were co-isolated within samples. Single Nucleotide Polymorphism-based analysis revealed complex colonizations by highly diversified, clonally related populations. Analyzing a large MRSA collection revealed new aspects of LR emergence: it emerges in specific subclonal lineages resulting from adaptive diversification of MRSA in the CF lung and this heterogeneity of intra-sample resistance may contribute to compromising antibiotic management.
Keywords: Staphylococcus aureus , cystic fibrosis, linezolid, resistance, emergence, siblings, diversity, adaptation, Geraldine clone, toxic shock syndrome toxin 1. Cystic fibrosis CF is a genetic disorder marked by a multi-organ disease due to a defect in the CFTR cystic fibrosis transmembrane conductance regulator protein, a transmembrane ion channel.
Alteration in transmembrane ion exchanges result in abnormal mucus decreasing microbial clearance and creating local conditions favorable to bacterial persistence. Regarding multidrug-resistant S. This could be related to the spread of community-acquired MRSA clones in the general population from these two distinct continents.
MRSA can establish different types of lung colonization, i. As detecting MRSA in the respiratory tract of CF patients is associated with lower lung function [ 3 ] and worse survival [ 4 ], and persistent infection is associated with a faster decline in the lung function [ 5 ], eradication is currently recommended.
