Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Hydroxyapatite nanoparticles HANPs have been applied in several biomedical fields.
However, its interaction with biological systems is less exploited. This study aimed to characterize HANPs, examine their influence on kidneys, and explore the potential protective effects of naturally extracted red pigment RP from Monascus purpureus against HANPs-induced renal toxicity.
The respective treatment was given daily by oral gavage to animals for 50 days which is the duration of the whole experiment. The renal toxicity caused by HANPs was manifested by aberrations in kidney function parameters, intensification of oxidative stress markers, and a decrease in the activity of antioxidant enzymes.
Meanwhile, co-treatment with different doses of biopigment and HANPs have reduced oxidative stress via their potent antioxidant effect. This was confirmed by pronounced improvement in the measured parameters along with the histological structural enhancement in a dose dependent manner compared to controls.
To sum up, RP from M. However, in the meantime, they played a role in NPs increased toxicological adverse effects 2 , 3 , 4 , 5. Hydroxyapatite nanoparticles HANPs are among the most important members of ultrafine materials which have called attention due to their biocompatibility, bioactivity, and osteoconductivity as they often serve as bone substitute in intra-osseous implantation or as implant coating materials 6 , 7.
