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The potency of these peptides as bifunctional antagonists was then tested, and compared to the parent fragments. Translational relevance was assessed by measuring antagonism of agonist-stimulated cAMP production in primary rat spinal cord cultures.
Background: The use of cannabis and its derivatives has increased during the last years due to their therapeutic potential. However, the exact mechanisms of action of cannabinoids are still limited.
It has been suggested that cannabinoids can exert their effects via the activation of cannabinoid receptors i. We investigated the role of CB receptors in the vasodilatory effects induced by capsaicin in human isolated coronary arteries HCAs. Thus, we can suggest that the CB and vanilloid systems may share a signaling pathway to modulate the vascular tone, which may provide novel therapeutic targets for vascular disorders e. Further studies should elucidate additional mechanisms involved in these responses.
