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Antigenic profiles that distinguish tubule-initiating prostate stem cells SCs from progenitor cells PCs and mature luminal cells LCs with less regenerative potential are unknown. Evaluation of tubule induction capability of fractionated cells was performed, in vivo, via a fully humanized prostate tissue regeneration assay. The results clearly demonstrate that sphere-forming ability is not predictive of tubule-initiation activity.
The subpopulations identified are of interest because they may play distinct roles as cells of origin in the development of prostatic diseases, including cancer. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
The work is made available under the Creative Commons CC0 public domain dedication. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
However, a consensus does not exist regarding the antigenic profile of a functionally pure human prostate SC population and how to distinguish multipotent tubule-initiating SCs from progenitors with more limited potential. Making such a distinction may have important implications in understanding the etiology of prostatic disease, including benign prostatic hypertrophy and cancer. In the human prostate, sphere-forming capability enables the selection of a subpopulation of epithelial cells with SC-like traits, including self-renewal and the ability to differentiate into tubular structures when implanted into immunocompromised mice [1] , [4].
Previous studies evaluating the antigenic profile of cells capable of forming prostaspheres indicate that they reside within the basal layer of normal prostatic ducts [1] , [4] , [11] , [12]. The aim of this work is to employ in vitro sphere culture and in vivo tissue regeneration assays to interrogate combinations of surface antigens that may further subdivide human prostate epithelial cells and enable functional separation of tubule-initiating SCs from progenitors with more limited capabilities.