Manfred Jung obtained his PhD on the synthesis of aromatic retinoids at the University of Marburg in From to he did a postdoc with T. Durst at the University of Ottawa Canada. In he received an offer for a full professorship to the University of Mainz that he declined and he is a Full Professor in Freiburg since He is currently the Dean of the Faculty of Chemistry and Pharmacy.
The topic of his research is Chemical Epigenetics with a major focus on histone modifying enzymes. His group is working on inhibitor synthesis, assay development and screening for inhibitors of reversible histone acetylation and methylation. Epigenetics is one of the major topics of modern biomedical research and is already a major focus in the Freiburg research landscape with international visibility.
We will establish a Research Focus on Chemical Epigenetics that deals with epigenetic mechanisms on a molecular level using our combined expertise in synthetic organic and medicinal chemistry, structural biochemistry and bioinformatics to address this topic in a highly synergistic manner. The main scientific focus of our project will be acetyl and methyl lysine binding proteins, so called histone code readers. Structural analyses provide the basis for identification and optimization of new chemical ligands for these proteins in a rational, bioguided fashion.
This will lead to new chemical tools that will allow dissecting cellular pathways involving these proteins as well as the analysis of their suitability as targets in drug discovery. The structural aim of this project is the preparation of a proposal for a structured PhD programme in Chemical Epigenetics with a strong international education perspective.
Document Actions Print this. Manfred Jung. External website. Email manfred. CV Publikationen Project. Selected Publications Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. Wagner, H. Greschik, T. Burgahn, K. Schmidtkunz, A. Schott, J. McMillan, L. Xiong, O. Fedorov, J. Jin, U. Oppermann, D. Matulis, R. Jung; Nucl. Acids Res. Metzger, D. Willmann, J. McMillan, I. Forne, P. Metzger, S. Gerhardt, K. Petroll, A.
