Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. An increasing number of evidences indicate microbes are implicated in human physiological mechanisms, including complicated disease pathology. Some microbes have been demonstrated to be associated with diverse important human diseases or disorders.
Through investigating these disease-related microbes, we can obtain a better understanding of human disease mechanisms for advancing medical scientific progress in terms of disease diagnosis, treatment, prevention, prognosis and drug discovery. Based on the known microbe-disease association network, we developed a semi-supervised computational model of L aplacian R egularized L east S quares for H uman M icrobeβ D isease A ssociation LRLSHMDA by introducing Gaussian interaction profile kernel similarity calculation and Laplacian regularized least squares classifier.
(mh=cm4lPLsYDLh8gvFs)0.jpg "Sluts Davenport")
In the framework of 5-fold cross validation, average AUC value of 0. In case studies, 9, 9 and 8 of top predicted microbes have been manually certified to be associated with asthma, colorectal carcinoma and chronic obstructive pulmonary disease by published literature evidence.
Our proposed model achieves better prediction performance relative to the previous model. A microbe or microorganism refers to a microscopic living organism which could be single-celled or multicellular.
With the deepening of research, microbes were basically classified into several species: bacteria, fungi, viruses, archaea, protozoa and others 1 , 2. Therefore, it is not surprising that multitudes of commensal microbes colonize in human body, such as skin 3 , lung 4 , gut 5 and oral cavity 6. It is generally believed that microbial cells in our body outnumber our own cells by a ratio of to-1 7. With the advent of high-throughput sequencing technology and analytic system, people have realized the critical role of microbe and carried out related investigations.
