Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation.
The patients were randomly divided into 2 groups. The majority of subjects in both groups experienced either no or mild improvement. In TCA group, mean improvement was 4. The majority of patients reported poor satisfaction.
Both modalities did not demonstrate a significant clinical nor dermoscopic response. Further larger multi centre studies with different concentration and combination modalities are required to detect promising treatments for vitligo. Vitiligo is an acquired pigmentary skin disorder by the absence of pigmentary cells from the epidermis that results in white macules and patches on the body.
The condition is usually associated with few autoimmune disorders, with thyroid abnormalities are the commonest one 1. The etiology of vitiligo is unknown but there are different theories to explain its pathogenesis. Vitiligo presents clinically with signs and symptoms of white spots on the body distributed symmetrically and more obvious in people with dark skin 2.
A number of genetic, environmental and behavioral interactions are among the contributing factors for progression or remissions in vitiligo 3. Despite not yet fully elucidated; induction of inflammation of viable melaoncytes followed by post inflammatory hyperpigmentation remains to be a proposed mechanism of TCA for activation of repigmentation in vitilgo patches 9. Methoxsalen is a psoralen produced naturally by various plants e. The use of topical methoxsalen in the treatment of vitiligo involves applying the medication directly to the affected areas of the skin.
