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Fibroblasts play a pivotal role in cancer progression. In prostate cancer, fibroblasts have been shown to induce growth, confer castration-resistance, and increase metastatic potential. To further understand how fibroblasts respond to hypoxic tumor microenvironments that are frequently observed in prostate cancer, here we have characterized the effects of hypoxia on normal prostate fibroblast metabolites as detected by high resolution 1 H magnetic resonance spectroscopy.
We found that hypoxia induced metabolic changes in normal prostate fibroblasts that mimicked the metabolites detected in prostate cancer associated fibroblasts CAFs , highlighting the potential role of hypoxia in the transition of normal fibroblasts to CAFs.
Zent J and Guo LW. Cell Physiol Biochem. Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane. Nat Commun. Nat Cell Biol. Metabolic reprogramming of stromal fibroblasts through pmTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell. Clin Cancer Res. A human prostatic stromal myofibroblast cell line WPMY a model for stromal-epithelial interactions in prostatic neoplasia.
Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism. Pacheco-Torres J, Shah T,. Investigating the effects of hypoxia on fibroblast invasion and metabolism.
ISMRM , abstract Synopsis Fibroblasts play a pivotal role in cancer progression. Introduction Fibroblasts are versatile cells that produce several extracellular matrix ECM proteins such as collagen 1 and extradomain A containing fibronectin, as well as degradative enzymes such as matrix metalloproteinases 1. Fibroblasts play an important role in wound healing, and in different pathological conditions such as the extensive fibrosis observed in chronic conditions, and in cancer progression.