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Cutaneous squamous-cell carcinoma cSCC , also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer , is one of the three principal types of skin cancer , alongside basal-cell carcinoma and melanoma. Compared to basal cell carcinoma, cSCC is more likely to spread to distant areas. The most significant risk factor for cSCC is extensive lifetime exposure to ultraviolet radiation from sunlight.
Genetic predispositions, such as xeroderma pigmentosum [ 17 ] and certain forms of epidermolysis bullosa , [ 18 ] also increase susceptibility to cSCC. The condition originates from squamous cells located in the skin 's upper layers.
Research, both in vivo and in vitro , indicates a crucial role for the upregulation of FGFR2 , part of the fibroblast growth factor receptor immunoglobin family, in cSCC cell progression.
Preventive measures against cSCC include minimizing exposure to ultraviolet radiation and the use of sunscreen. As of , approximately 2. SCC of the skin begins as a small nodule and as it enlarges the center becomes necrotic and sloughs and the nodule turns into an ulcer, and generally are developed from an actinic keratosis.
Once keratinocytes begin to grow uncontrollably, they have the potential to become cancerous and produce cutaneous squamous-cell carcinoma.