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No use, distribution or reproduction is permitted which does not comply with these terms. PriMe takes a longitudinal perspective on these three disorders from the at-risk stage to the first-episode, relapsing, and chronic stages. PriMe aims at reducing mortality on different levels, e. PriMe aims to add a precision medicine framework to the DZPG that will propel deeper understanding, more accurate prediction, and personalized prevention to prevent disease chronicity and mortality across mental illnesses.
This framework is structured along the translational chain and will be used by PriMe to innovate the preventive and therapeutic management of SZ, BPD, and MDD from rural to urban areas and from patients in early disease stages to patients with long-term disease courses. Research will build on platforms that include one on model systems, one on the identification and validation of predictive markers, one on the development of novel multimodal treatments, one on the regulation and strengthening of the uptake and dissemination of personalized treatments, and finally one on testing of the clinical effectiveness, utility, and scalability of such personalized treatments.
Keywords: precision medicine, mortality, schizophrenia, depression, bipolar disorder, comorbidities. Every year, approximately one third of adults in Germany and Europe meet the diagnostic criteria for a mental illness. Overall, there is a need for a deeper understanding, more accurate prediction, and personalized prevention of disease chronicity across these disorders and mental illnesses more broadly. The six German Centers for Health Research DZGs carry out research on common diseases of particular importance for the health of the German population.
