Official websites use. Share sensitive information only on official, secure websites. Address correspondence to Steven Y. Tong, Steven. Tong menzies. Fowler, Jr. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev doi: Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections.
This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions. S taphylococcus aureus is both a commensal bacterium and a human pathogen.
Simultaneously, it is a leading cause of bacteremia and infective endocarditis IE as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. Our aim in this review is to summarize recent developments in the epidemiology, pathophysiology, clinical manifestations, and management of these key S.
We do not address in any significant depth issues regarding colonization or mechanisms of drug resistance and refer readers to recent reviews 1 β 6.
Bacteremia is perhaps the best-described manifestation of S. Multiple studies have now documented the prevalence, prognosis, and outcome of S. However, many basic questions about the epidemiology of SAB, particularly in the world's nonindustrialized regions, remain unanswered. Furthermore, there continues to be a paucity of high-quality evidence to guide the management of SAB.
