Official websites use. Share sensitive information only on official, secure websites. There was no intervention. Adherence was self-reported over the past 4 wk peg-interferon or 7 d ribavirin.
After adjustment for baseline differences, education improved adherence [Odds ratio OR 1. As pointed out by the WHO[ 1 ], poor adherence to treatment is a worldwide issue in all chronic conditions, which results in poor health outcomes and increased health care costs[ 2 , 3 ].
Adherence to therapy is critical in the treatment of chronic hepatitis C virus HCV infection. The current gold standard therapy is a combination of peg-interferon alfa and ribavirin[ 8 , 9 ]. Therapy requires weekly subcutaneous injections, twice-daily oral dosing and frequent visits, with blood tests. Side effects occur in nearly all patients.
A review of the literature confirmed that treatment response is influenced not only by HCV genotype and viral load, but also by patient-related factors including adherence[ 14 ]. Moreover, optimal HCV healthcare requires further efforts from providers in communicating with patients, as advocated in France by hepatitis C experts and the Health Ministry[ 15 , 16 ], and shown in studies using patient questionnaires in North America[ 17 , 18 ].
We carried out a large survey named CheObs to evaluate adherence to chronic hepatitis C treatment in the real-life setting in France. We observed that some patients received therapeutic education by a third party other than the investigator , at the discretion of the investigators, during the study period.
