What role do omega-6 fatty acids play in cardiovascular disease and diabetes? Scientists from Mannheim, together with researchers from Heidelberg, Frankfurt and Hangzhou in China, have investigated the breakdown of omega-6 fatty acids and gained new insights into how their oxidation products influence the metabolism. Under the leadership of Professor Dr. Jens Kroll from the European Center for Angioscience ECAS of the Medical Faculty Mannheim, Heidelberg University, the researchers identified a breakdown product of omega-6 fatty acids and developed a model in zebrafish to examine the undesirable effects of this oxidation product, known as tt-DDE for trans,trans-2,4-decadienal.
A simulation study conducted by a team from the Technical University of Munich TUM demonstrates that a soft drink tax in Germany would have significant positive effects. In all of the simulated variants evaluated, less sugar was consumed and the rate of illness dropped. This would be a way to reduce costs to the national economy and alleviate the burden on the health care system. There is, however, a difference between taxes aimed at reducing soft drink consumption and taxes aimed at bringing about changes in product formulation.
These novel compounds lead to substantial weight loss, offering a revolutionary approach to patients worldwide. Although the hormone glucose-dependent insulinotropic polypeptide GIP was already shown by Helmholtz Munich scientists to decrease body weight via the brain GIP receptor, the underlying neurons through which GIP acts in the brain remained unknown.
Scientists led by Dr. These new findings are published in 'Nature Metabolism'. Theresia Sarabhai as the recipient of its Rising Star Award In conjunction, Sarabhai also received a coveted EFSD Fellowship for her research on insulin resistance in adipose tissue. In recent years, new insights have been gained into the heterogeneity of diabetes and its impact on the risk of complications.
This is resulting in new ways to prevent and treat diabetes. A new consensus report on precision medicine in diabetes prevention and therapy has now been prepared by international scientists with the participation of DZD researchers and published in the scientific journal 'Nature Medicine'.
